Read A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution Online Free - A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril.
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans.
Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?
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July 03, 2017
This book's coauthor, Jennifer Doudna, together with Emmanuelle Charpentier published a seminal 2012 paper that demonstrated that CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) could be used for programmable gene editing. The whole field of CRISPR has since become the hottest...
August 20, 2017
A great explanation of CRISPR Cas9 that recounts the research that uncovered it and makes a case for determining how we will responsibly control and wield this powerful tool in future gene editing. The ethical and moral questions are very difficult, and Doudna/Sternberg don't pretend to have soli...
June 26, 2017
Last time a book gave me this feeling of awe and amazement was reading Stephen Hawkin's "Brief history of time" 20 years ago. It speaks volumes to Jennifer's ability to distilled the essential on this complex topic that I left feeling I had a good grasp on the subject (albeit with my mind racing...
July 18, 2017
I won this book in a Goodreads giveaway! Definitely a subject I'd be interested in but maybe I wouldn't have pursued it otherwise, so thanks Goodreads.
Me being me, I found myself turned off by the personal element of the book. It's a good writing technique - it personalizes all the scientific inf...
August 18, 2017
A CRACK IN CREATION: Gene Editing and the Unthinkable Power to Control Evolution. (2017). Doudna & Sternberg. ***.
This work is a short history of CRISPR, a term that refers to a region of bacterial DNA. The acronym stands for “clustered regularly interspaced short palindromic repeats.” The a...
December 09, 2017
Pretty dry and hyper-technical (or at least poorly explained) re: the details surrounding the CRISPR discovery and how CRISPR works: I learned much, much more from Siddhartha Mukherjee’s “The Gene” re: genetics in general and what all this DNA/RNA stuff does (which then makes understanding CRISPR...
January 26, 2018
This was the ground breaking paper (not sure if I should post the link to the full article here) published by the authors of this book along with other researchers that made way for a technology that has alarmed scientists with its potential to the extent t...
August 20, 2017
I want to say this book is a must-read. It is really, really good. The scientific explanations are concise and distill what I'm sure are really complex processes into something digestible - and does a much better job of this than Siddhartha Mukherjee's book, in my opinion. The technology of gene...
January 08, 2018
This is simply amazing research and I am in awe of Doudna. The book is really sciency, which is good, but I was less interested in the play by play than in the possibilities (no, I am not a scientist). Nevertheless, a great read.
September 28, 2017
From studying how bacteria fight off viral infections to development of the Life (not personal but humanity) changing technologies of CRISPR/Cas9. This book a great, mostly understandable primer on the development and technologies used. Understandable even for a 61 year old who has no microbiolog...