Read A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution Online Free - A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril.
Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans.
Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?
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July 03, 2017
This book's coauthor, Jennifer Doudna, together with Emmanuelle Charpentier published a seminal 2012 paper that demonstrated that CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) could be used for programmable gene editing. The whole field of CRISPR has since become the hottest...
August 20, 2017
A great explanation of CRISPR Cas9 that recounts the research that uncovered it and makes a case for determining how we will responsibly control and wield this powerful tool in future gene editing. The ethical and moral questions are very difficult, and Doudna/Sternberg don't pretend to have soli...
June 26, 2017
Last time a book gave me this feeling of awe and amazement was reading Stephen Hawkin's "Brief history of time" 20 years ago. It speaks volumes to Jennifer's ability to distilled the essential on this complex topic that I left feeling I had a good grasp on the subject (albeit with my mind racing...
July 18, 2017
I won this book in a Goodreads giveaway! Definitely a subject I'd be interested in but maybe I wouldn't have pursued it otherwise, so thanks Goodreads.
Me being me, I found myself turned off by the personal element of the book. It's a good writing technique - it personalizes all the scientific inf...
August 18, 2017
A CRACK IN CREATION: Gene Editing and the Unthinkable Power to Control Evolution. (2017). Doudna & Sternberg. ***.
This work is a short history of CRISPR, a term that refers to a region of bacterial DNA. The acronym stands for “clustered regularly interspaced short palindromic repeats.” The a...
June 28, 2017
It's important to understand the benefits of genetic engineering are nothing short of miraculous. Like the author, I look forward to the day when genetic therapies become so commonplace as to be unremarkable.
That said, this is the second scariest book I've read. The first was Marc Goodman's "Futu...
July 11, 2017
The biology of CRISPR/CAS in book are well done, but the ethics of its use less so -both in terms of clarity and thoughtfulness (not surprising given authors' background), but also some very wishful thinking (including little consideration of the inevitability of the race to the bottom (due marke...
August 22, 2017
Humans have reshaped the physical world for millennia, but the effects have never been as dramatic as they are today. Industrialization has caused climate change that threatens life around the globe. The biological world is also undergoing profound, human induced change. For billions of years, li...
June 29, 2017
*Disclaimer: I was provided with a free copy of this book in exchange for an honest review*
I was definitely intrigued by the backstory of CRISPR and this books tells a fascinating story of one of the key scientists involved. As this book is aimed at a general audience, it does spend a large porti...
July 17, 2017
The punchline of this book is masterfully hidden in the introduction, someday it might even be considered immoral to not do anything about human suffering even after having the ability to do so. This book is a fascinating account of a new gene editing technology called CRISPR. The technology is v...